China (Mainland)
AT13148 CAS NO.1056901-62-2
- Min.Order: 50 Milligram
- Payment Terms: T/T,MoneyGram,Other
- Product Details
Keywords
- 1056901-62-2 AT13148
- 98% purity AT13148
- AT13148 in stock
Quick Details
- ProName: AT13148
- CasNo: 1056901-62-2
- Molecular Formula: C17H16ClN3O
- Appearance: Off-white solid
- Application: Laboratory research
- DeliveryTime: As your request
- PackAge: As your request
- ProductionCapacity: Metric Ton/Day
- Purity: ＞98％
- Storage: 2 years 4°C
- Transportation: By air
- LimitNum: 50 Milligram
- Grade: Pharma Grade
Superiority
High purity
NMR、HPLC will be offered
Fast delivery
Custom synthesis is available
Details
AT13148 is an orally active small molecule inhibitor of PKB/Akt and p70S6 kinase, key enzymes in the PI3K/PKB/mTOR tumor cell survival pathway. More than 50 percent of all tumors have an abnormality in this pathway leading to increased Akt activity and enhanced potential for tumor cell survival. In addition, clinical trials have highlighted that activation of this survival pathway is a common resistance mechanism for some cytotoxics (for example, platinum agents) and targeted therapies (for example, BRAF and EGFr inhibitors). By targeting the pathway at two key steps, AT13148 has the potential to be a very effective inhibitor of AKT dependent tumors. PKB inhibitors such as AT13148 have potential for use as both single agents and in combination with cytotoxics and other molecularly targeted agents in the treatment of a range of solid tumors.