China (Mainland)
AZD1152-HQPA CAS NO.722544-51-6
- Min.Order: 50 Milligram
- Payment Terms: T/T,MoneyGram,Other
- Product Details
Keywords
- AZD1152-HQPA
- 722544-51-6 AZD1152-HQPA
- 722544-51-6 Barasertib
Quick Details
- ProName: AZD1152-HQPA
- CasNo: 722544-51-6
- Molecular Formula: C26H30FN7O3
- Appearance: Off-white solid
- Application: laboratory research
- DeliveryTime: As your request
- PackAge: As your request
- ProductionCapacity: Metric Ton/Day
- Purity: ＞98％
- Storage: RT
- Transportation: by air
- LimitNum: 50 Milligram
- Grade: Pharma Grade
Superiority
High purity
NMR、HPLC will be offered
Fast delivery
Custom synthesis is available
Details
AZD-1152 is a novel acetanilide-substituted pyrazole-aminoquinazoline prodrug that is converted rapidly to the active drug AZD-1152 hydroxy-QPA (AZD1152-HQPA) in human plasma. AZD1152-HQPA is a specific inhibitor of the enzymatic activity of Aurora kinase, with selectivity for Aurora B (IC50 of 0.37 nM versus 1368 nM for Aurora B and A kinases, respectively); the inhibitor had even less activity against a panel of greater than 50 other serine-threonine and tyrosine kinases including FLT3, JAK2, and Abl. Preliminary studies showed that AZD-1152 was active against a variety of solid tumors including colon, breast,and lung cancers.